Increased surface P2X4 receptor regulates anxiety and memory in P2X4 internalization-defective knock-in mice. Bertin E*, Deluc T*, Pilch KS*, Audrey Martinez A, Pougnet JT, Doudnikoff E, Allain AE, Bergmann P, Russeau M, Toulmé E, Bezard E, Koch-Nolte F, Séguéla P, Lévi S, Bontempi B, Georges F, Bertrand S, Nicole O and Boué-Grabot E. (*co-first authors). Molecular Psychiatry. DOI : 1038/s41380-019-0641-8.
Increased cell surface levels of the ATP receptor P2X4 are observed in several brain and peripheral disorders, suggesting an involvement of P2X4 in the pathogenesis of pathologies such as Alzheimer’s disease and Amyotrophic lateral sclerosis. In this study, published in the journal Molecular Psychiatry, we present a novel knockin mouse model providing a tool to specifically increase P2X4 levels on surfaces of different cell types and thereby mimicking the previously observed pathological upregulation. Our results show that increased P2X4 levels on the surface of excitatory forebrain neurons of knockin mice alter activity-dependant synaptic plasticity phenomena, impair learning and memory and reduce anxiety-like behaviour. These findings emphasize the key role of increased P2X4 on neuronal surfaces in various neuropsychiatric disorders. Moreover, we characterize and validate this knockin mouse model as a unique tool that will allow to further decipher the cell-specific roles of P2X4 in various physiological and pathological contexts.
We are delighted to announce the winners of the Neurasmus consortium merit-based scholarships awarded only to the self-funded 2016-2018 student intake.
After a carefully evaluation of the study performance the merit base scholarships were awarded by the Neurasmus Consortium, among the winners the following students names listed below according to alphabetical order:
Being Neurasmus provided me with the opportunity to challenge myself in the scientific and personal aspects. While I had a general idea of what interested me in Neuroscience before applying, my experience in the program reshapped my whole perception of the field, providing me with multiple opportunities to explore practically and theoretically new topics that were unfamiliar to me. Thanks to these resources, I was able to do a internship during my first year of master in a behavioral lab as a personal challenge I decided to undertake. My experience in this lab, together with the network I was able to build thanks to the cross-continent collaboration that Neurasmus facilitates, led me to propose a collaborative project between my French lab and a Canadian lab in which I am currently working for my PhD. Neurasmus opened the door to get funding for this project as I was highly considered for the position due to the top quality education the Neurasmus program is known for. I am greatly thankful for the opportunities Neurasmus allowed me to have and for that reason I am active member of the alumni community and I know that, even after graduation, I can always rely on the network I have created through Neurasmus for my future career
Paula Gomez Sostres
Living abroad during the Neurasmus program helped me to become comfortable with environments that are totally foreign to me. Thus, my experience with Neurasmus led me to apply for a clinical rotation in Slovenia this summer, which is at my own expense. This scholarship will help me cover the cost of this rotation, another example of the Neurasmus program facilitating my intercultural discovery and professional development -- even after graduation!
Neurasmus has been a wonderful and unforgettable experience which sparked my passion and shaped my knowledge of Neuroscience. More importantly, Neurasmus has allowed me to study and work in three different countries and enabled me to meet, interact and collaborate with people from all around the world. I’m sincerely honored to have been selected as recipient of the Neurasmus Consortium Merit-Based Scholarship which will be used towards achieving my career goals and continuing education in the field of Neuroscience.
Being part of Neurasmus has provided me with the unique opportunity to study Neuroscience and Neuropathology at the best Universities in Europe. This allowed me to perform innovative research during several internships and to acquire intercultural competences, crucial for scientific collaboration. For me, Neurasmus was a major stepping stone for my scientific career and I am very honoured to receive the Neurasmus consortium merit-based scholarship. I will use the financial support to travel to academic conferences to present my current research and exchange ideas with colleagues from my field. Thank you!
After Neurasmus, I started my PhD as an extension of my master's thesis project in the same lab. My Neurasmus experience played a substantial role in my securing independent funding for my PhD - the program's mobility and diversity was frequently a positive talking point during interviews. Building on contacts I had made during my master's, my PhD project combines clinical, pre-clinical, and methodological research through collaborations with two institutes in Berlin and Leipzig. Being part of the Neurasmus family has also helped motivate me to be more engaged with the broader scientific community - as a science writer and advocate for better scientific practice. In the four years since completing the Neurasmus program, I published five papers (two as first author), which have helped me form a solid foundation for my career as a clinician-scientist.
Neurasmus has been chosen as a Success Story & Good Practice Example from the 14 best projects out of 377 Erasmus Mundus projects.
Read about on the Erasmus+ Project Results Platform